Monday, March 16, 2020

Can you live forever?

Well, maybe I should say, can you leave longer in a healthy condition? This is what David Sinclair is explaining here and here.

From his  book, Lifespan, by David Sinclair (this summary was done by Andrej Rusakov on the comments of the above video):

- Low levels of leucine, isoleucine, and violin BCAAs correlate with increased lifespan
- Exercise turns on the genes that make us young again
- Hunger and calorie restriction plays a big role in vitality and longevity
- Get exposed to cold
- Shift to vegetarian/vegan diet
- Sauna 7x a week may be great
- NMN molecule boosts NAD - he takes it in supplements + Metformin
- Nicotinamide Riboside (NR) is converged to NMN, it’s cheaper, but it doesn’t raise NAD levels as well as MNM does
- Rapamycin is very powerful, but still very toxic for you
- Stoke development of brown fat (it activates when you get cold)

What David Sinclair does:
- 1g (1000 milligrams) of NMN+ 1g of resveratrol shaken into his homemade yogurt every morning
- 1g of Metformin
- Daily doze of vitamin D, vitamin K2
- 83mg of aspirin
- Keeps sugar, bread and pasta intake as low as possible, no deserts
- skips one meal a day (largely skips lunch)
- Tests blood for dozens of biomarkers every few months and moderates them with food and exercise if not optimal levels
- Takes a lot of steps and runs up stairs daily
- Exercises, sauna, cold plunge pool
- Mostly plant-based diet
- Avoids microwave plastic, excessive UV exposure, X-rays and CT scans
- No smoking
- Stays in the cool side during the day and when he sleeps at night
- Keeps his BMI: 23-25
- Supplements: only from a large manufacturers with good reputation, seek highly pure molecules: >98%; looks for GMP on the label (Good Manufacturing Practices)

Reimbursement/costs

For the US, can't tell private costs but one can search for Medicare/Medicaid reimbursements . For instance: Search physician fee schedu...