Sunday, December 25, 2022

Cells FAQ

How many are there in the body? ~37 Trillion (37e12) + 10-100 Trillion microbial cells in the microbiota.

How many by tissue? This nice supplemental material to this article is so far the closest I've found to answer this (thanks to these guys).

How often they divide? See same material.

How many types? According to this site, about 200. There are whole collaborations like the Human Cell Atlas trying to list these. It is not obvious how to classify what makes a cell fall on a different group than another. 


https://www.biolegend.com/en-us/cell-markers

https://en.wikipedia.org/wiki/List_of_human_cell_types_derived_from_the_germ_layers

How to distinguish them? 

What makes us call a type different from another type?

At what point they are differentiated?






What is CD? Molecules expressed on the cell surface that allow for their differentiation by scientist but also by the immune system (and not necessarily in that order :)). Full list here.



Here I list few known ones:

  • Stem cells:
    • Embryonic
    • Somatic or adult << We would count only these in an adult
  • Red blood cells: erythrocytes. Fun fact: they do not have nuclei
  • White blood cells (leukocytes):
    • Granulocytes
      • Neutrophils
      • Eosinophils
      • Basophils
    • Agranulocytes
      • Lymphocytes:
        • B-cells
        • T-cells
      • Monocytes.
  • Platelets: actually megakaryocytes 
  • Nerve cells: neurons
  • Neuroglial (aka glial) cells
    • Astrocytes
    • Oligodendrocytes
    • Microglial cells
    • Ependymal cells
    • Schwan cells
    • Satellite cells
  • Muscle (aka myocytes) cells:
    • Skeletal muscle cell: multinucleated, cm long, form voluntary muscles (muscles controlled by the somatic nervous system)
    • Cardiac muscle cell, aka cardiomyocytes 
    • Smooth muscle cell, responsible for involuntary contractions.
  • Cartilage cells, aka chondrocytes
  • Bone cells:
    • Osteoblasts
    • Osteoclasts
    • Osteocytes
    • Lining cells.
  • Skin cells:
    • Keratinocytes
    • Melanocytes
    • Langerhans cells
    • Merkel cells: involved in touch
  • Endothelial cells: blood vessel lining
  • Epithelial cells: lining of cavities in the body
  • Fat cells, aka adipocytes and lipocytes 
    • White fat cells
    • Brown fat cells
  • Sex cells: sperm or ova (eggs)

(Last Update: 1/12/2023)

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